Chemomechanical Coupling of Molecular Motors: Thermodynamics, Network Representations, and Balance Conditions
نویسندگان
چکیده
منابع مشابه
Chemomechanical Coupling of Molecular Motors
Living cells contain a large number of molecular motors: membrane pumps, stepping motors, growing filaments, and molecular assemblers such as polymerases and ribosomes. In many cases, these nanomachines are driven by the energy released from fuel molecules such as adenosine triphosphate (ATP). The coupling of the motor to these nonequilibrium reactions provides energy which is converted into co...
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The directed movement of molecular motors is studied theoretically within a general class of nonuniform ratchet models in which the motor can attain M internal states and undergo transitions between these states at K spatial locations. The functional relationship between the motor velocity and the concentration of the fuel molecule is analyzed for arbitrary values of M and K. This relationship ...
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Molecular motors are first and foremost molecules, governed by the laws of chemistry rather than of mechanics. The dynamical behavior of motors based on chemical principles can be described as a random walk on a network of states. A key insight is that any molecular motor in solution explores all possible motions and configurations at thermodynamic equilibrium. By using input energy and chemica...
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The biochemical cycle of a molecular motor provides the essential link between its thermodynamics and kinetics. The thermodynamics of the cycle determine the motor's ability to perform mechanical work, whilst the kinetics of the cycle govern its stochastic behaviour. We concentrate here on tightly coupled, processive molecular motors, such as kinesin and myosin V, which hydrolyse one molecule o...
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F1-ATPase (F1) is the smallest rotary motor protein that couples ATP hydrolysis/synthesis to rotary motion in a highly reversible manner. F1 is unique compared with other motor proteins because of its high efficiency and reversibility in converting chemical energy into mechanical work. To determine the energy conversion mechanism of F1-ATPase, we developed a novel single-molecule manipulation t...
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ژورنال
عنوان ژورنال: Journal of Statistical Physics
سال: 2007
ISSN: 0022-4715,1572-9613
DOI: 10.1007/s10955-007-9425-7